By PTI |Bengaluru | Published: July 14, 2019 2:25:03 pm Karnataka: Supreme Court to rule today, says Speaker’s powers need relook More Explained Advertising Bracing for SC hearing and trust vote, Karnataka parties hide their MLAs Visuals of Nagaraj boarding a chartered flight have also surfaced on local news channels.Nagaraj, who was Housing Minister in the Kumaraswamy government before he resigned, however, maintained that he was still in the Congress party.“Sudhakar has switched off his phone, and is not available for the last two days. After pacifying and convincing Sudhakar, I will try to bring him back. Because we both had resigned together, so we want to be united. I have informed this to Congress leaders,” Nagaraj told reporters here before leaving his residence.Stating that he was still in the Congress, he said leaders, including Chief Minister H D Kumaraswamy and CLP leader Siddaramaiah, have asked him to withdraw the resignation. “I’m also trying for it (withdraw). Only thing is that I have to meet Sudhakar, I haven’t met him. I will meet him, he should be somewhere,” he said, adding “my intention is that we have to withdraw it (resignation) together.”After almost day-long negotiations on Saturday, it appeared that Congress had made some headway in pacifying Nagaraj, who had hinted that he might consider withdrawing his resignation, but fell short of making any final announcement.A day after Kumaraswamy made a surprise announcement in the Assembly that he would seek a trust vote, marathon meetings were held by coalition leaders, including Siddaramaiah, Kumaraswamy and Minister D K Shivakumar, with Nagaraj on Saturday.However, Nagaraj on his part maintained his stand that he will take any call on withdrawal only after talks with Sudhakar, as they both had decided to resign together. Karnataka: SC to rule today, says Speaker’s powers need relook Best Of Express In undecided Congress, first open call for Priyanka: She should be party chief NRC deadline approaching, families stranded in Assam floods stay home Advertising Advertising Karnataka crisis: SC to give verdict on rebel MLAs plea against Speaker tomorrow The Hoskote MLA had maintained that he intended to take a final decision on the withdrawal of his resignation after talks with Chikkaballapura MLA K Sudhakar, as both had together submitted resignation to the Speaker on July 10. (File)Efforts by coalition leaders to mollify rebel Congress MLA M T B Nagaraj seem to have failed as he has flown to Mumbai Sunday, according to sources. The Hoskote MLA had even said he would also try to pacify Sudhakar and convince him to withdraw the resignation.Responding to a question on his decision if he was unable to meet Sudhakar, Nagaraj said, “Then, what should be my decision, I will decide it tomorrow morning.”Asked what he would do if Sudhakar did not agree to withdraw his resignation, Nagaraj said, “I will think about it and decide.”Nagaraj is among the five rebel Congress MLAs, who had moved the Supreme Court on Saturday against the Assembly Speaker K R Ramesh Kumar not accepting their resignation.MLAs Anand Singh, K Sudhakar, N Nagaraj (MTB), Munirathna and Roshan Baig have sought impleadment in the already pending application filed by the 10 other rebel MLAs on which hearing is scheduled for Tuesday.The coalition government is on a sticky wicket with 16 MLAs — 13 of the Congress and three of the JD(S) — resigning their assembly membership. Besides, two independent legislators, who were made ministers recently to provide stability, have quit the cabinet.The independents — H Nagesh and R Shankar — too have withdrawn support to the coalition government and are now supporting the BJP.The ruling coalition’s strength in the House is 116 (Congress 78, JD(S) 37 and BSP one), besides the speaker.With the support of the two independents, the opposition BJP has 107 MLAs in the 224-member House. Explained: Kulbhushan Jadhav case file Related News Leaders of the Congress-JD(S) coalition held negotiations with Nagaraj on Saturday in a bid to woo him back to save the H D Kumaraswamy-led government in Karnataka that is on the brink of collapse.The Hoskote MLA had maintained that he intended to take a final decision on the withdrawal of his resignation after talks with Chikkaballapura MLA K Sudhakar, as both had together submitted resignation to the Speaker on July 10.According to the sources, Nagaraj is now on his way to Mumbai to join Sudhakar, who is said to be along with other MLAs who have quit and are camping there. If the resignations of the 16 MLAs are accepted, the ruling coalition’s tally will be reduced to 100. The speaker has a vote too. Post Comment(s)
Advertising In undecided Congress, first open call for Priyanka: She should be party chief Related News Rahul Gandhi appeals to Cong workers to help in relief ops in flood-affected areas Rahul Gandhi exempted from personal appearance in defamation case in Surat Rahul Gandhi with Gujarat Pradesh Congress Committee leaders on Friday at an Ahmedabad metropolitan court.Congress leader Rahul Gandhi was on Friday granted bail in the defamation suit filed against him by the Ahmedabad District Cooperative Bank and its chairman Ajay Patel. The Ahmedabad court accepted the bail application on conditions that either Gandhi be arrested or he appears in the court. The Court will hear the matter again on September 7. Advertising By Express Web Desk |New Delhi | Updated: July 12, 2019 6:43:59 pm Though there are reports that before going to the court, Rahul will attend a roadshow which will be organised by the party’s supporters in Gujarat, state Congress spokesperson Manish Doshi denied any such arrangement, stating that the Congress leader will briefly interact with his supporters on his way to the Metropolitan Court.“…In the evening, he will interact with the party’s leaders for half an hour in a closed event,” said Doshi. Commenting on the suit, Doshi said, “This is a conspiracy by the BJP to frame and harass Rahul for his fight for the common people. He had exposed the wrongdoings of the BJP and had stood by the common people. Rahul will keep fighting for the truth and the entire party is with him in this.” 23 Comment(s) Soon after he arrived in Ahmedabad, Gandhi thanked his political opponents, RSS and BJP, for “providing him with platforms and opportunities” to ensure his “ideological battle” against them reached the public.“I’m in Ahmedabad today, to appear in another case filed against me by my political opponents in the RSS/BJP. I thank them for providing me with these platforms and opportunities to take my ideological battle against them to the public. Satyameva Jayate.Congress leader @rahulgandhi address the media after a court hearing in Gujarat. He has pleaded not guilty to defamation charges and has been released on bail. https://t.co/FfSx9re8xe pic.twitter.com/oQnLGwnLLv— The Indian Express (@IndianExpress) July 12, 2019This is Congress leader’s first visit to the Gujarat capital after the party’s humiliating defeat in the recently held Lok Sabha elections.Summons were issued to Gandhi and Congress spokesperson Randeep Surjewala in a criminal defamation suit filed by the Ahmedabad District Cooperative Bank and its chairman. Union Home Minister Amit Shah is a director of the bank. The suit alleged that the Congress leaders had claimed that the bank was involved in a scam to swap Rs 750 crore in scrapped notes with valid currency within five days of demonetisation in November 2016.
Advertising Advertising Related News Israel, Russia to cooperate on foreign troop exit from Syria: Benjamin Netanyahu Syrian state media says US struck army base, US denies The US Treasury added three Hezbollah figures to its sanctions list, including two Lebanese MPs and a security official.The move widens a US campaign that since 2017 has designated 50 people and entities linked to Hebzollah, which Washington classifies as a “terrorist” organisation.Nasrallah called the new sanctions “an honor” that came as “part of the ongoing battle” against Hezbollah and its allies.“What’s new is the affront to the Lebanese state,” Nasrallah said.“At the end of the day, Hezbollah is an important part of the country. The Lebanese government will tell the Americans, as it has before, that these are a part we can not ignore.” “What’s new is the affront to the Lebanese state,” Sayyed Hassan Nasrallah said. (Reuters)The leader of Hezbollah said on Friday that Washington was seeking to open channels of communication despite ramping up sanctions against the Iran-backed movement’s officials. US President Donald “Trump’s administration is seeking to open channels of communication to Hezbollah in Lebanon through mediators. … These are the American pragmatists,” Sayyed Hassan Nasrallah said in an interview with Hezbollah’s al-Manar TV without elaborating.There was no immediate comment from the US State Department on the assertion.New sanctions this week marked the first time the United States has targeted lawmakers of the heavily-armed Shi’ite Hezbollah, which is part of Lebanon’s coalition government. A US State Department official said on Tuesday that the message was that the rest of the Lebanese government “needs to sever its dealings” with these officials.Lebanese Prime Minister Saad al-Hariri said on Wednesday that the sanctions moved in a “new direction,” but would not affect government work. (Reporting by Ellen Francis, editing by G Crosse. Karnataka: Supreme Court to rule today, says Speaker’s powers need relook NRC deadline approaching, families stranded in Assam floods stay home In undecided Congress, first open call for Priyanka: She should be party chief Hezbollah leader warns Israel over attacks in Syria By Reuters |Beirut | Updated: July 13, 2019 4:05:36 pm Post Comment(s) Best Of Express
Source:https://news.uga.edu/researchers-seek-vaccine-travelers-diarrhea/ Reviewed by James Ives, M.Psych. (Editor)Sep 26 2018Every year, millions of people have vacations and business trips ruined when they succumb to “traveler’s diarrhea” during their journeys. A major cause of traveler’s diarrhea is bacteria called Enterotoxigenic E. coli, or ETEC. A joint effort between the University of Georgia and the University of Texas at Austin has discovered how ETEC works to cause disease. They are using this information in an effort to develop a preventive vaccine for travelers.The researchers, led by the University of Georgia’s Dr. Stephen Trent–a professor in the department of infectious diseases–teamed up with the U.S. Navy Medical Research Center and the Johns Hopkins University Bloomberg School of Public Health to study samples taken directly from citizens who volunteered to become infected with ETEC.”If we can understand how ETEC causes disease, we can develop new vaccines to prevent infections,” Trent said.Ingesting contaminated food or water can lead to ETEC infection, which can cause diarrhea for up to a week. Considering the fact that up to 200 million people become infected annually, an estimated 1 billion days of human productivity are lost every year due to ETEC infections.Visiting the doctor to get vaccinated before a trip can prevent travelers from catching a disease. Unfortunately, there are no available vaccines to prevent ETEC infections, so travelers must constantly be concerned about what they eat and drink while on vacation.The group examined how ETEC behaved inside humans during infection compared to how it behaved in the laboratory. They were surprised to find that ETEC produced more toxins when grown in the laboratory than it did in human infection samples. Bewildered, the researchers sought to figure out why. They discovered that ETEC could sense oxygen in the atmosphere, and that controlled the amount of toxins produced by ETEC. This explained their surprising data: There is more oxygen in the atmosphere than there is in the digestive tract, which resulted in the differing levels of toxin expression.Related StoriesSwimming pools could be breeding grounds for diarrhea-causing germsComputer-generated flu vaccine enters clinical trials in the USResearchers develop improved vaccine for meningitis and bloodstream infectionsThis breakthrough gives researchers hope that they have identified the “cue” that ETEC uses to determine when to make toxins that cause disease. How ETEC causes disease via toxins has been studied exhaustively for decades. Previous groups have identified numerous factors that contribute to toxin production in ETEC, but this is the first-time oxygen has been identified as a major player in ETEC virulence. Lead author and University of Texas graduate student Alex Crofts said, “We think ETEC can sense the oxygen given off by our own cells as a cue to produce toxins.”The group now hopes to use this oxygen-sensitive ETEC response against the bacteria to prevent infections. “Beyond toxins, we found ETEC regulates many other factors in response to oxygen, and some of those are promising new targets for future vaccines,” explained Trent. “ETEC is a global burden on society, and we are doing all we can to advance our understanding of the disease.”
Reviewed by James Ives, M.Psych. (Editor)Oct 10 2018Researchers with the Veterans Affairs Portland Health Care System and Oregon Health & Sciences University found that a history of binge drinking made male and female mice react differently to traumatic stress. The research may help scientists understand why men and women seem to handle both alcohol and stress differently.The results were published in the September 2018 issue of the journal Alcohol.A history of binge drinking is a strong predictor of alcohol dependence, and alcohol use disorder is often characterized by repeated episodes of binge drinking. Excessive drinking is the fourth leading preventable cause of death in the United States, and accounts for nearly 6 percent of deaths globally.Stress may shift alcohol use from recreational to excessive, according to the researchers.Posttraumatic stress disorder in particular has been linked with the development of alcohol use disorders. Of people with PTSD, 28 percent of women and 52 percent of men also have an alcohol use disorder. The rate of PTSD and alcohol use disorder together is even higher in the VA system, with reports of almost 70 percent in hospitalized veterans. The relationship between the two conditions goes both ways: PTSD symptoms appear to promote excessive drinking, and alcohol abuse worsens PTSD symptoms.Past research has shown that abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis–interconnected biological systems that control how the body reacts to stress–are present in both PTSD and alcohol use disorder. Differences between the sexes have also been seen in how the HPA axis responds to stress.So how do these biological differences between the sexes affect the complex relationship between alcohol use and PTSD?To answer this question, the researchers looked to a mouse study.They simulated binge drinking in mice by providing alcohol as the only source of hydration for the rodents. A group of male and female mice had seven intermittent binge drinking sessions, followed by a month of abstinence from access to alcohol. Another group of male and female mice drank water as a control.The researchers then intermittently exposed the mice to dirty rat bedding to cause stress. Previous research has shown that the odor of predators can produce behavioral and physiological responses in rodents similar to those seen following traumatic stress in humans. An earlier phase of the study showed that the dirty rat bedding increased anxiety-related behavior and increased the levels of corticosterone–a stress hormone–in both male and female mice.Lead author Dr. Deborah Finn, a research pharmacologist at the VA Portland Health Care System and professor in the department of behavioral neuroscience at OHSU, explains that her team used a device called the “elevated plus maze” to measure anxiety-related behavior in the mice.”We measure the amount of time the mouse spends in the open and closed arms in the apparatus, and some other behaviors, during a five-minute test. A mouse that exhibits more anxiety-related behavior will spend more time in the closed, protected arms, whereas a mouse that exhibits less anxiety-related behavior will spend more time in the open arms.”Before and after the mice were exposed to the dirty rat bedding, they were offered two bottles to drink from, one with alcohol and one with water. Each bottle was equipped with a “lickometer,” a device that recorded both the amount and frequency of drinking.Male mice that previously had drunk water increased their alcohol licks by 24 percent after four stress periods over 22 days, compared with their baseline drinking prior to the beginning of the stress period. For male mice in the binge drinking group, ethanol licks increased by 65 percent. Drinking behavior after stress–how often the mice drank and how much they drank each time they went to the bottle–increased across time for the male binge group but not the control group.Related StoriesStress during early pregnancy may reduce future fertility of offspringStudy reveals how genetic message to produce healthy heart tissue is altered during stress, agingEarly adversity could make individuals more vulnerable to stress-related drinking during adulthoodIn the female mice, no difference appeared between the binge-drinking group and the water group. Stress caused female mice to drink more alcohol, but the binge group did not increase their intake more than the control group, as was seen in the males. The female binge mice increased their alcohol licks by 5 percent, while the control group increased by 6 percent.However, there were two clear subgroups in the females. One group of female mice increased their drinking much more than the group average, suggesting they were more sensitive to stress. For female mice in the stress-sensitive subgroup, binge females increased their drinking by 87 percent and control females increased their drinking by 214 percent, compared to the pre-stress baseline drinking levels. This result suggested to the researchers that this group had a more dramatic response to stress, when compared to the responses in males, but prior binge drinking did not exacerbate the response to stress as in the males.The researchers found neurochemical and physiological differences between males and females, in addition to the changes in alcohol drinking behavior. When testing blood plasma, they found that predator stress exposure significantly increased corticosterone levels in mice that were consuming alcohol, with higher levels in females than in males. This finding is consistent with evidence for sex differences in HPA axis responsivity to stress.However, the stress-induced increase in corticosterone levels was lower than that observed in the mice that had never consumed alcohol, especially in the male mice. This result suggested to the researchers that a history of alcohol drinking might dampen the stress response to predator odor, particularly in male mice.The researchers also used a test called a Western blot to measure protein levels in the brain tissue of the mice. They focused on the prefrontal cortex and hippocampus, two brain regions that are important in the stress response. Two proteins involved in regulating the stress response, corticotropin releasing factor receptor 1 (CRF-R1) and glucocorticoid receptor (GR), were significantly increased by traumatic stress exposure and a history of alcohol drinking in the prefrontal cortex and hippocampus of female mice. Similar increases were not observed in the male mice. The clear sex difference in CRF-R1 and GR levels suggested that the HPA axis may respond differently in males and females to repeated traumatic stress and the long-term alcohol drinking.While the research was conducted using mice, it could have implications for how humans react to both excessive drinking and traumatic stress.Ample evidence from past research shows that men and women are affected differently both by stress and by alcohol. Lifetime prevalence of PTSD is reported to be twice as high in women as in men, whereas prevalence of alcohol use disorder with PTSD is higher in males than in females.Men and women also tolerate alcohol differently, past studies show. In general, men seem to have a higher tolerance for alcohol than women. Past research suggests that there may be more complex chemistry involved than just body weight. For example, men may metabolize alcohol faster than women because their bodies produce more of an enzyme that breaks down alcohol in the liver. Women also develop alcohol-related problems such heart disease, liver damage, and brain damage after fewer years of heavy drinking, compared with men.The researchers plan to use their model to look for biological and molecular mechanisms that could confer sensitivity or resilience to binge drinking and traumatic stress exposure. They emphasize that traumatic stress and binge drinking together have a greater effect than either on its own, and that men and women may need to be treated differently for these conditions. The lab research could eventually help lay the groundwork for new treatment strategies for veterans and others with both PTSD and alcohol use disorders.Source: https://www.research.va.gov/currents/1018-Study-shows-how-binge-drinking-and-stress-affects-male-female-mice-differently.cfm
Source:https://www.ehu.eus/en/web/campusa-magazine/-/empathy-on-aggression-in-children Reviewed by James Ives, M.Psych. (Editor)Apr 17 2019The research group in the Psychobiology section of the Department of Basic Psychological Processes and their Development of the UPV/EHU’s Faculty of Psychology has spent many years studying aggressive behaviour in children. “We tackle the study of aggressive behaviour through a range of variables of a biological, psychological and social type,” explained Eider Pascual-Sagastizabal, a lecturer in the department. A recent piece of work published in the scientific journal Psichoneuroendocrinology reports on the data relating to the study into hormonal levels of testosterone, estradiol and cortisol and the capacity for empathy of 8-year-old girls and boys.”We’re talking about a type of normative, mild aggressive behaviour inherent in the human being him-/herself. We work with the normative population, in other words, they are not children with behavioural problems,” pointed out Pascual-Sagastizabal, one of the authors of the work. The main aim of this work was to “see whether there was any interaction on a biological and psychological level that could account for aggressive behaviour in children. A further aim was to find out whether this behaviour can be explained by means of various psychobiological mechanisms in children”, she added. The data emerging from the study indicate that “there are in fact psychobiological markers of aggressive behaviour, in other words, there are variables of a psychobiological type that account for aggressive behaviour in children”, said the researcher.80 boys and 59 girls aged 8 (in year 3 of Primary Education) participated in the study, which involved measuring their hormonal levels of testosterone and estradiol (sexual hormones) and cortisol (hormone associated with stress). At the same time, “we measured their empathy through a questionnaire that we handed out to their parents, and aggressive behaviour was assessed in the classroom itself: the rest of the classmates evaluated each other’s behaviour,” she said.A bid to understand the complexity of human behaviourAs the researcher explained, the results of the study revealed that “empathy and hormones could together account for aggressive behaviour. In fact, the interactions were different for boys and for girls”. The researcher pointed out that “the reason why a girl is not very aggressive could be explained partly by their high levels of empathy and their low levels of testosterone”, in other words, it was established that the girls who combine these two psychobiological elements are less aggressive. In boys, however, “with testosterone being as famous as it is in relation to aggressive behaviour, our data do not correlate testosterone with empathy to account for aggressive behaviour”, specified Pascual, since boys with higher levels of cortisol and lower levels of empathy than the rest turned out to be more aggressive. By contrast, the levels of estradiol did not reflect any interaction with empathy in either case.Related StoriesWhy Mattresses Could be a Health Threat to Sleeping ChildrenChaos in the house and asthma in children – the connectionGuidelines to help children develop healthy habits early in lifeHowever, Pascual-Sagastizabal said that these results correspond to “this sample, to this moment and to this age. It is not a representative sample; for it to be representative we would need to handle vary large samples. Representativeness was at no moment the aim that we were pursuing”. The data correspond to a small group of boys and girls, “but they are fundamental data and more research needs to be done”, she added.These researchers aimed to expand knowledge about aggressive behaviour: “We tried to understand the complexity of a human behaviour, and within that complexity to add as many variables as possible”. It is a piece of basic research, “essential for understanding why there are things that work when they are applied or if one intervenes, and why at other times they don’t work”, she stressed. For example, “it has always been said that the more empathy there is, the less aggressive behaviour there is, but what we are contributing is that it may not always be like that”. So the researcher concluded that “we professionals need to work on different levels of the same reality, which in this case is aggressive behaviour”.
Reviewed by Alina Shrourou, B.Sc. (Editor)Jun 20 2019People with fibromyalgia show variations in microbiome composition Scientists have found a correlation between a disease involving chronic pain and alterations in the gut microbiome.Fibromyalgia affects 2-4 percent of the population and has no known cure. Symptoms include fatigue, impaired sleep and cognitive difficulties, but the disease is most clearly characterized by widespread chronic pain. In a paper published today in the journal Pain, a Montreal-based research team has shown, for the first time, that there are alterations in the bacteria in the gastrointestinal tracts of people with fibromyalgia. Approximately 20 different species of bacteria were found in either greater or are lesser quantities in the microbiomes of participants suffering from the disease than in the healthy control group.Greater presence or absence of certain species of bacteria”We used a range of techniques, including Artificial Intelligence, to confirm that the changes we saw in the microbiomes of fibromyalgia patients were not caused by factors such as diet, medication, physical activity, age, and so on, which are known to affect the microbiome,” says Dr. Amir Minerbi, from the Alan Edwards Pain Management Unit at the McGill University Health Centre (MUHC), and first author on the paper. The team also included researchers from McGill University and Université de Montréal as well as others from the Research Institute of the MUHC.Dr Amir Minerbi, McGill University Health Centre: We found that fibromyalgia and the symptoms of fibromyalgia – pain, fatigue and cognitive difficulties – contribute more than any of the other factors to the variations we see in the microbiomes of those with the disease. We also saw that the severity of a patient’s symptoms was directly correlated with an increased presence or a more pronounced absence of certain bacteria – something which has never been reported before.” Are bacteria simply the markers of the disease?At this point, it’s not clear whether the changes in gut bacteria seen in patients with fibromyalgia are simply markers of the disease or whether they play a role in causing it. Because the disease involves a cluster of symptoms, and not simply pain, the next step in the research will be to investigate whether there are similar changes in the gut microbiome in other conditions involving chronic pain, such as lower back pain, headaches and neuropathic pain.Related StoriesNon-pathogenic bacteria engineered as Trojan Horse to treat tumors from withinGrowth problems in preterm infants associated with altered gut bacteriaBacteria in the birth canal linked to lower risk of ovarian cancerThe researchers are also interested in exploring whether bacteria play a causal role in the development of pain and fibromyalgia. And whether their presence could, eventually, help in finding a cure, as well as speed up the process of diagnosis.Confirming a diagnosis and next steps towards finding a cureFibromyalgia is a disease that has proved difficult to diagnose. Patients can wait as long as 4 to 5 years to get a final diagnosis. But this may be about to change.”We sorted through large amounts of data, identifying 19 species that were either increased or decreased in individuals with fibromyalgia,” says Emmanuel Gonzalez, from the Canadian Center for Computational Genomics and the Department of Human Genetics at McGill University. “By using machine learning, our computer was able to make a diagnosis of fibromyalgia, based only on the composition of the microbiome, with an accuracy of 87 per cent. As we build on this first discovery with more research, we hope to improve upon this accuracy, potentially creating a step-change in diagnosis.””People with fibromyalgia suffer not only from the symptoms of their disease but also from the difficulty of family, friends and medical teams to comprehend their symptoms,” says Yoram Shir, the senior author on the paper who is the Director of the Alan Edwards Pain Management Unit at the MUHC and an Associate Investigator from the BRaiN Program of the RI-MUHC. “As pain physicians, we are frustrated by our inability to help, and this frustration is a good fuel for research. This is the first evidence, at least in humans, that the microbiome could have an effect on diffuse pain, and we really need new ways to look at chronic pain.”How the research was doneThe research was based on a cohort of 156 individuals in the Montreal area, 77 of whom suffer from fibromyalgia. Participants in the study were interviewed and gave stool, blood, saliva and urine samples, which were then compared with those of healthy control subjects, some of whom lived in the same house as the fibromyalgia patients or were their parents, offspring or siblings.The researchers’ next steps will be to see whether they get similar results in another cohort, perhaps in a different part of the world, and to do studies in animals to discover whether changes in bacteria play a role in the development of the disease. Source:McGill UniversityJournal reference:Minerbi, A. et al. (2019) Altered microbiome composition in individuals with fibromyalgia. Pain. doi.org/10.1097/j.pain.0000000000001640
‘Success rates have stabilized,’ said Dr de Geyter, ‘although outcome in egg donation and with use of frozen embryos is still moving upwards. The biggest upwards movement, however, is from treatments with frozen eggs, which have been revolutionized by the widespread introduction of vitrification.’ Twenty-two countries reported activity in egg donation treatment with frozen banked eggs (11,196 cycles), achieving a pregnancy rate of 43.7% and delivery rate of 29.9%.Dr de Geyter also noted that the availability of assisted reproduction treatment remains very patchy in Europe, with Denmark and Belgium each offering more than 2500 treatment cycles per million population, while others (such as Austria and Italy) offer considerably fewer. A study calculated that the global need for advanced fertility treatments was around 1500 cycles per million population per year. ‘Only a minority of European countries meet this need,’ said De Geyter. Source:European Society of Human Reproduction and Embryology Clinics in Europe continue to favor ICSI over IVF by around two-to-one (359,858 ICSI, 128,626 IVF cycles), a pattern now evident throughout the world. ICSI was developed in the early 1990s as a specific treatment for male infertility (low sperm counts, poor sperm quality) but is now clearly used for fertilization in non-male cases. Pregnancy rates are higher with five-day old embryos (blastocysts) than with three-day, another widely favored strategy. Pregnancy rates from egg donation continue to rise (now at about 50%), making egg donation the most successful treatment available. The rate of twin pregnancy continues to decline in Europe, in 2016 to around 15%. Similarly, the rate of single embryo transfers continues to rise – from 11% in 1997 to above 40% in 2016. Reviewed by Alina Shrourou, B.Sc. (Editor)Jun 25 2019The latest annual data collected by ESHRE from European national registries (for 2016) show another rise in the cumulative use of IVF in the treatment of infertility, although success rates after IVF or ICSI appear to have reached a peak, with pregnancy rates per started treatment calculated at 27.1% after IVF and 24.3% after ICSI. The figures, although indicative of a slight decline in pregnancy rate, continue a recent trend of conventional IVF cycles performing better than ICSI.The one treatment in which cycle numbers and success rates continue to rise is in frozen embryo cycles in which embryos cryopreserved in storage are thawed for transfer in a later cycle. Pregnancy rate per started treatment in 2016 was 30.5%, an increase over 2015 of 1.3%. Around one half of the total European cycles analyzed by ESHRE were transfers from frozen embryos, also an increase over 2015. Dr Christian de Geyter, chair of ESHRE’s European IVF Monitoring Consortium, said the number of frozen embryo transfers was likely to increase as more and more clinics adopt a single embryo transfer policy (and thus store more embryos) or take up ‘freeze-all’ strategies to avoid embryo transfer in an initial stimulated cycle.In Europe, Spain remains the most active country in assisted reproduction, with a record a record 140,909 treatment cycles performed. Spain continues to set the pace ahead of Russia (121,235 cycles), France (104,733) and Germany (969,226). The cycles monitored by ESHRE include treatments with IVF, ICSI, intrauterine insemination and egg donation.(2)The report covers a total of more than 800,000 treatment cycles performed in 2016, with 165,000 babies born – and represents the largest and most accurate snapshot of assisted reproduction in Europe.(2) Dr de Geyter will present the results today in Vienna at the 35th Annual Meeting of ESHRE.He estimates that around 84% of all European assisted reproduction fertility treatments are now included in the ESHRE monitoring program – although this year (for 2016) without ther inclusion of any data so far from the UK, which usually performs around 60,000 treatments a year.Related StoriesMaternal obesity may negatively affect children’s lung developmentPregnant women with migraine more often have complications during pregnancy and childbirthOpioids are major cause of pregnancy-related deaths in UtahAmong other findings:
Reviewed by James Ives, M.Psych. (Editor)Jul 11 2019In a sit-down interview with CNN, 2020 Democratic presidential primary candidate and former Vice President Joe Biden touted the Obama administration’s passage of the Affordable Care Act, asserting that this law evened out the playing field when it came to insurance coverage of mental and physical health.”We made parity between mental health and physical health,” Biden told CNN’s Chris Cuomo. “It was a fundamental breakthrough in how we thought about how things should work.”This gets at a health care issue that — as a federal appeals court weighs Obamacare’s constitutionality — is now particularly relevant. Did the ACA create equal coverage of mental and physical health?We decided to investigate. We contacted the Biden campaign and never heard back.But our own reporting shows that while Biden’s claim is mostly accurate concerning the health law’s provisions, its implementation has yet led to trigger the systemwide changes necessary to achieve the goal of parity.One Problem, Two LawsThe ACA, which became law in 2010, does include provisions meant to strengthen access to and insurance coverage of mental health care. But it wasn’t the first statute to take on this challenge.Two years earlier, before Barack Obama became president, Congress passed the Mental Health Parity and Addiction Equity Act. It said that if insurance offered by large employers — an organization employing more than 50 people — included mental health benefits, it had to structure those benefits, as well as associated copayments or caps on visits, equal to — “at parity” with — physical health benefits.A key thing to note, though, is that this 2008 law did not specifically mandate coverage of mental health services.Obamacare went further by requiring most plans to cover mental health and substance abuse. And it extended the parity requirement beyond large-employer-sponsored coverage to plans offered by small employers and those bought on the individual market.Health economists estimate that the ACA extended mental health benefits to 62 million people.”It substantially expanded the reach of the parity law,” said Sherry Glied, a health economist and dean at New York University.Both Glied and Richard Frank, a health economics professor at Harvard University, agreed that the first part of Biden’s claim checks out. The health law certainly brought in new standards for parity and expanded the rules already on the books. (Frank and Glied both served in the Obama administration.)But the law also operates in tandem with the earlier legislation. One could reasonably question whether it constitutes a “fundamental breakthrough” or represents the next step in a broader trajectory.Holes In The SystemPerhaps more important, though, is the current state of parity. To be sure, the ACA’s requirements created a clear set of parity standards. In some respects, though, these standards exist on paper but don’t always play out in practice.”It’s huge that the guaranteed protections are there,” said JoAnn Volk, a research professor at Georgetown University. “The challenges remain in delivering on them.”That’s because some coverage inequities are easier to spot than others. If a health plan caps how many times you can see a psychiatrist but doesn’t do so for an allergist or oncologist, that’s a clear violation. If mental health care visits have higher coinsurance than do physical health visits, that’s also obviously illegal.Evidence suggests those quantitative barriers are less common now than they were before the passage of these two laws. Those changes, Glied said, have most clearly benefited people with severe psychiatric conditions.Related StoriesOnline training program helps managers to support employees’ mental health needsHospitals’ decision to transfer kids with mental health emergencies is based on insurance typeIU-connected startup working to enable precision medicine for mental health issues, chronic painBut other barriers remain — many of which are quite nuanced and therefore more difficult to spot and enforce.For instance, health plans aren’t supposed to require prior authorization for a psychiatrist visit unless they also do so for a “comparable” physical health service. The problem, of course, is how the word “comparable” is defined and interpreted.”Even if you’re not trying to exploit the ambiguities but are trying to do a good job, you still might get into some controversial situations where folks might disagree, and disagree on a legit basis,” Frank said.And, both Frank and Glied noted, there are cases in which insurance plans might try to take advantage of those ambiguities.Take, for instance, the question of “medical necessity.” Insurance plans can argue that a mental health service isn’t required for someone’s well-being. Advocates argue that, even in the wake of the parity laws, that argument is used as an excuse to deny care, and that it is used more often for psychiatric cases than for, say, treating someone with diabetes or a hip injury.These barriers more often affect people with less severe mental health conditions, but who still require care, Glied said.States have amped up their enforcement, in part due to federal support, Volk said. But they often rely on reports from consumers who have experienced parity violations, which assumes people will realize their plan has broken the law.And issues exist beyond parity. Research suggests that insurance networks still fall short when it comes to including an adequate or even robust panel of behavioral health providers who accept their coverage.That’s in part because of distinctions in mental health care — whether someone specializes in cognitive behavioral therapy or talk therapy, for instance, or a psychiatrist’s age or gender or life experiences. Plus, many behavioral health specialists simply don’t take insurance.Those issues, Frank said, come in part because of the distinct complexity of mental health coverage.”Mental health is not just one thing — it’s a whole bunch of illnesses. You want people to get the care they need,” Frank said. That means that devising effective policy “is a balancing act.”Our RulingBiden told CNN that the ACA “made parity between mental health and physical health,” describing that policy as a “fundamental breakthrough.”It’s clear the 2010 law’s parity requirements had a major impact: 62 million people gaining coverage is nothing to sneeze at.But the ACA wasn’t the first piece of legislation to take this issue on. And major issues remain when it comes to making sure insurance treats mental health needs the same way it does physical health ones.Biden’s statement is accurate, but it would benefit from additional information. We rate it Mostly True. This article was reprinted from khn.org with permission from the Henry J. Kaiser Family Foundation. Kaiser Health News, an editorially independent news service, is a program of the Kaiser Family Foundation, a nonpartisan health care policy research organization unaffiliated with Kaiser Permanente.
In an article published today in Frontiers in Robotics and AI, which covers all theory and applications of robotics, technology, and artificial intelligence, a team of academics led by Professor Sylvie Delacroix, Professor in Law and Ethics at the University of Birmingham, sets out that VR has a very important role to play in helping GPs to further develop the wide range of intuitive and perceptual skills that are essential to their practice.While some of those skills can be taught pretty straightforwardly, others are harder to impart without the benefit of experience and role models. The ability to pick up signs that a child may be suffering from abuse at home is one of those skills that cannot easily be taught.The project looked at how an immersive virtual reality environment could address these challenges.Dr. Sylvia Xueni Pan of Goldsmiths, University of London, led the development of an immersive virtual reality environment replicating a GP’s surgery, where GP participants were able to interact with virtual, avatar patients in the same way as they would in a ‘real’ consultation.In the virtual scenario, the GP encountered a patient with a complex medical condition. He was accompanied by his son, whom he treated so aggressively as to cause the son to flinch. The tell-tale signals of child abuse were made more subtle in one condition, and more obvious in the other, with expert advice provided by Dr. Caroline Fertleman, of University College London, a paediatrician with particular expertise in child-safeguarding.All the characters were animated using motion capture data captured from professional actors. This animation and dialogue elements were then integrated into the animation engine.A total of 64 GPs with different levels of experience were involved in the study. Its aim was to establish whether levels of experience would have any impact on the GPs’ ability to pick up child-safeguarding concerns, and whether more experienced GPs would find it easier to pick up subtle, rather than obvious, signs of child-safeguarding concerns. A three-year research project led by a University of Birmingham academic, working with colleagues from Goldsmiths and University College London, has indicated that virtual reality (VR) could become a vital tool for training General Practitioners (GPs) to look out for hard-to-detect signs of child abuse. The project’s main measurement was the quality of the note left by the GP at the end of the virtual consultation. These notes were reviewed by a panel of 10 people with relevant training in safeguarding, to reflect the fact that there is no single right answer when it comes to child-safeguarding strategies. This panel rated the note according to the extent to which they were able to identify and take the necessary steps required in relation to the child safeguarding concerns.Professor Delacroix says: “It is very difficult to study how GPs spot signs of abuse, given the number of factors that may interfere with this in a real-life, professional setting. It is encouraging that the system developed by this project showed that the GPs’ level of experience did not impact upon their ability to pick up on a parent’s level of aggressive behaviour towards their child.”Our results also showed that GPs who are less stressed, less neurotic, more agreeable and extroverted tend to be better at raising potential child abuse issues in their notes. These results not only indicate the considerable potential of virtual reality as a training tool—they also highlight fruitful avenues for further research and potential strategies to support GPs in their dealing with highly sensitive, emotionally charged situations.”The VR lead of the work, Dr. Sylvia Xueni Pan of Goldsmiths, adds: “An advantage of our approach is that, unlike with actors, we have absolute control over our virtual characters. This means we can subtly alter the behaviour and responses of these virtual patients. Our results show that medical doctors responded to this, as those given less obvious behavioural cues were not as effective at recording concerns as those given more obvious cues.”The medical lead of the work, Dr. Caroline Fertleman from UCL says: “For ethical reasons it would be impossible to recreate this kind of sensitive scenario using child actors. What we have shown, for the first time, is that we can create virtual reality characters of abused children and their parents that doctors believe in and interact with in a realistic way enabling them to learn how to spot the subtle warning signs of abuse.” Credit: CC0 Public Domain Police officers at risk of PTSD when investigating child sexual abuse cases More information: Xueni Pan et al. A Study of Professional Awareness Using Immersive Virtual Reality: The Responses of General Practitioners to Child Safeguarding Concerns, Frontiers in Robotics and AI (2018). DOI: 10.3389/frobt.2018.00080 Explore further Citation: Study shows virtual reality could hold the key to GPs spotting child abuse (2018, July 13) retrieved 18 July 2019 from https://phys.org/news/2018-07-virtual-reality-key-gps-child.html Provided by University of Birmingham This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
5% quota for Kapus may queer the pitch in AP Published on January 25, 2019 COMMENTS SHARE SHARE EMAIL The ruling Telugu Desam Party (TDP) in Andhra Pradesh, under sustained pressure from the Opposition YSR Congress and the BJP, is offering a multitude of sops such as hiking old age pension to ₹2,000 per month from ₹1,000 and ₹10,000 financial assistance to women’s self-help group (SHGs), clearly showing that it is leaving no stone unturned to get re-elected.However, Will these last-minute welfare measures work? The YSR Congress Party is claiming that the TDP is only copying its schemes announced by Jaganmohan Reddy during the recently-concluded Padayatra (marathon walk across the 13 districts of the State). ‘Nothing to learn’The CM is clearly in a panic mode. Doubling pension is a promise that we have made and the State government has announced it in a hurry from January this year. Why couldn’t he do it earlier? asked YSR Congress leaders. State Finance Minister Yanamala Ramakrishnudu was dismissive, “Surely, we have not sunk low enough to learn from Jagan. Anyhow, what do we have to learn from him? Should we learn how to perpetrate mega scams, robbing the exchequer of thousands of crores?” Meanwhile, Chief Minister N Chandrababu Naidu has also laid foundation stones for several projects such as the Kadapa steel plant, the Kakinada petro-chemical complex and the Ramayyapatnam port in Prakasam district. The Opposition remains critical of his actions. The Kadapa steel plant proposal is ridiculous. There is no iron ore linkage and no clearances have been obtained. Many of them are under Centre’s control and yet the CM has gone ahead with foundation-laying, they said. SHARE COMMENT RELATED N Chandrababu Naidu, Chief Minister, Andhra Pradesh – BY ARRANGEMENT
NDRF personnel prepare for emergencies in view of Cyclone Fani, in Bhubaneswar, Wednesday, May 1, 2019. – PTI SHARE SHARE EMAIL COMMENT May 02, 2019 Published on SHARE Twenty-eight fully equipped teams have been deployed in and around Puri where the cyclonic storm is expected to make a landfall Friday noon. Over 4,000 specialised personnel as part of 81 NDRF teams have been deployed to deal with the ‘extremely severe’ Cyclone ‘Fani’ which is likely to affect Odisha, Andhra Pradesh and West Bengal upon its landfall on Friday.NDRF chief SN Pradhan told PTI that about 50 teams have been pre-positioned in the coastal areas of Odisha, Andhra Pradesh and West Bengal, which are feared to be affected, while another 31 teams have been kept on standby.Twenty-eight fully equipped teams have been deployed in and around Puri in Odisha, as the cyclonic storm is expected to make a landfall there Friday noon, the NDRF Director General (DG) said.Similarly, 12 teams have been deployed in Andhra Pradesh and six in West Bengal. The rest of the teams, that comprise about 50 personnel each, have been kept on standby in these states.Pradhan said a Deputy Inspector General (DIG) and a commandant-rank officer have also been tasked to monitor the activities of the rescue and relief teams from ground in Odisha’s capital Bhubaneswar and Puri.The teams have been equipped with additional boats, satellite phones, medical equipment, medicines, tree cutters, pickup and common mobility vehicles, and other gadgets, he said. The force has also activated a round-the-clock control room at its headquarters here and a team of officials is in constant touch with the India Meteorological Department (IMD) and the disaster response units of the three states. NDRF teams have also been kept on alert in Tamil Nadu and Kerala. “Cyclone ‘Fani’ is expected to cross the Odisha coast between Gopalpur and Chandbali to the south of Puri on May 3. NDRF teams are creating awareness among the locals in vulnerable areas about the measures to be taken to deal with the cyclonic storm and other eventualities. The state administration has set up a number of relief camps,” an NDRF spokesperson said.The spokesperson said the NDRF teams have doctors, paramedics, engineers, deep divers and are equipped with boats, buoys, life jackets, scuba sets and latest communication equipment like quick deployable antenna (QDA), HF/VHF sets so that communication links function even if normal communication network fails.Fani lays centred over West Central Bay of Bengal, about 430 km south-southwest of Puri in Odisha, 225 km south-southeast of Vishakhapatnam in Andhra Pradesh and 650 km south-southwest of Digha in West Bengal, as per the latest bulletin of the IMD. COMMENTS
Odisha: BJP chief whip forced to stay on footpath, no official residence or guest house allottedManjhi, a three-time MLA from Keonjhar, said he has raised the issue many times but of no avail, even though it has been a month since he took oath as a member of the House.advertisement Asian News International KeonjharJuly 14, 2019UPDATED: July 14, 2019 14:07 IST Manjhi, a three-time MLA from Keonjhar, said he has raised the issue many times but of no avail. (Source: ANI)HIGHLIGHTSMajhi claimed that he has not been allotted an official residence or guest houseThe BJP chief whip said he is being forced to stay on the footpathHe also said his personal belongings, including official files, were robbedBJP chief whip in Odisha Assembly, Mohan Charan Majhi, has claimed that he has not been allotted an official residence or guest house in Bhubaneswar, forcing him to stay on the footpath.Speaking to ANI, Manjhi, a three-time MLA from Keonjhar, said he has raised the issue many times but of no avail, even though it has been a month since he took oath as a member of the House.”I stay on the footpath and work from there due to non-allotment of a house even after a month of taking oath as a member of the Odisha Assembly. I have not even been allotted a room in the state guest house,” he alleged.Majhi also claimed that his personal belongings, including official files, were robbed.”Once my Personal Assistant was assaulted and my files were also looted. I have requested for security and a residential quarter. Along with me, others who have not been allotted residences also raised this issue,” he added.The Keonjhar legislator informed that after drawing the attention of Assembly Speaker SN Patro on his plight, he has been assured that the matter will be resolved soon.”I have been assured by Speaker Patro that soon the matter will be resolved,” he said.Also read | Delhi: Police hunts BJP leader’s speedster nephew who did stunts around Rashtrapati BhavanAlso read | 107 Congress, TMC, CPM MLAs will join BJP, claims Mukul RoyAlso watch | Leaderless Congress headed towards self-destruction?For the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byAnumika Bahukhandi Tags :Follow BJPFollow OdishaFollow Mohan Charan Majhi Next
War of words between Jagan Mohan Reddy and Chandrababu Naidu in Andhra AssemblyA war of words between Andhra Pradesh Chief Minister YS Jagan Mohan Reddy and leader of opposition N. Chandrababu Naidu rocked the state Assembly on Friday.advertisement Next Press Trust of India AmaravatiJuly 13, 2019UPDATED: July 13, 2019 00:23 IST Andhra Pradesh Chief Minister YS Jagan Mohan Reddy (right) and leader of opposition N Chandrababu Naidu.A war of words between Andhra Pradesh Chief Minister YS Jagan Mohan Reddy and leader of opposition N. Chandrababu Naidu rocked the state Assembly on Friday.Pandemonium prevailed in the House as there were heated exchanges between the two leaders during a debate on interest-free loans for farmers.As the debate on the issue was taken up for second day due to persistent demands by opposition Telugu Desam Party (TDP), Naidu reeled out statistics from different documents to deny the allegations by Jagan Reddy that the previous government did not implement zero per cent interest scheme.As the chief minister had on Thursday dared Naidu to resign and leave the House for failing to give even a penny to the farmers, Naidu hit back at Jagan Reddy by providing the statistics. “Will you resign now or apologise to people?” the TDP chief asked the chief minister, evoking protest from treasury benches.Countering Naidu, Jagan Reddy said the TDP government provided only Rs 600 crore for the scheme while it should have given Rs 11,600 crore in five years. He said Naidu was claiming a great achievement by giving just 5 per cent money.There were repeated interruptions when the chief minister was speaking. Irked over this, he remarked “We are 151. If we decide you will not be seen around.”When TDP leader Atchan Naidu tried to intervene, Jagan Reddy asked him to sit and taunted him. “The man is of this size, but the brain is not of that level. You don’t know what to speak and what not to speak,” said the chief minister.Speaker T. Seetharam also reprimanded the TDP members for repeatedly creating disruptions.YSR Congress Party (YSRCP) has 151 members in 175-member Assembly. The TDP’s strength is 23.ALSO READ | Andhra Pradesh: YS Jagan Mohan Reddy govt presents its first budgetALSO WATCH | Rahul Gandhi finally steps down as party president; Jaganmohan Reddy’s demolition spree; moreFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byAnupriya Thakur Tags :Follow Jagan Reddy
Next Press Trust of India DehradunJuly 12, 2019UPDATED: July 13, 2019 11:54 IST Rishikesh administration ordered stopping of public movement on ‘Lakshman Jhula’, citing its dilapidated condition. (Photo: ANI)HIGHLIGHTSThe bridge was closed on the recommendation of a team of expertsThey found most of its parts in “fail” or “collapse” conditionThe team recommended immediate closure of the bridge to all trafficLakshman Jhula, the iconic suspension bridge across the Ganga in Rishikesh, was closed to traffic Friday as experts feel it cannot sustain more load, officials said.The bridge was closed on the recommendation of a team of experts who found most of its parts in “fail” or “collapse” condition, Additional Chief Secretary Om Prakash said.The team recommended immediate closure of the bridge to all traffic and pedestrian movement as it was not in a condition to sustain any more load, he said.There has been an unprecedented rise in traffic and pedestrian movement along the bridge in recent times and the bridge towers appear to be leaning towards one side, he said.The decision was taken as keeping it operational could have been risky, the official said.”It is highly recommended that the bridge should be closed with immediate effect otherwise any big mishap can take place anytime,” the team of experts had said in its report to authorities.Built in 1923 over the Ganga river, Lakshman Jhula is an iconic landmark in this city of Uttarakhand that is renowned as a center for studying yoga and meditation.It connects Tapovan village in Tehri district on the western bank of the river with Jonk in Pauri district.One of the main attractions for tourists and devotees coming to Rishikesh, the pedestrian bridge also used by two-wheelers was named after Hindu mythological character Lakshman as it stands where he is said to have crossed the river with the help of jute ropes.Many successful Hindi movies and serials like “Ganga Ki Saugandh”, “Sanyasi” and popular detective serial “CID” have been shot at the Lakshman Jhula.Also Read | Karnataka: 1 dead, 8 rescued as under-construction building collapses in BengaluruAlso Watch | CST bridge collapse case: Structural auditor’s bail plea rejectedFor the latest World Cup news, live scores and fixtures for World Cup 2019, log on to indiatoday.in/sports. Like us on Facebook or follow us on Twitter for World Cup news, scores and updates.Get real-time alerts and all the news on your phone with the all-new India Today app. Download from Post your comment Do You Like This Story? Awesome! Now share the story Too bad. Tell us what you didn’t like in the comments Posted byChanchal Chauhan Rishikesh’s iconic Lakshman Jhula shut FOREVER after experts call it beyond repairThe bridge was closed on the recommendation of a team of experts who found most of its parts in “fail” or “collapse” condition, Additional Chief Secretary Om Prakash said. advertisement