AstraZeneca bets up to $6 billion on new Daiichi cancer drug

first_imgAstraZeneca has been bolstering its portfolio of cancer therapies, particularly ADCs, a major area of focus for the company as it also ploughs on with its coronavirus vaccine candidate.”We see significant potential in this antibody drug conjugate in lung as well as in breast and other cancers that commonly express TROP2,” AstraZeneca Chief Executive Pascal Soriot said, referring to a protein found on some cancer cell surfaces.JP Morgan analysts said the drug could bring $1 billion or more in annual sales, adding that since AstraZeneca’s upfront commitments are spread over three years, it could still keep previous dividend cover commitments.DS-1062, which targets the TROP2 protein, belongs to the ADC category of drugs, which link powerful cell toxins to antibodies that cling to cancer cells and spare healthy cells that are damaged during conventional chemotherapy treatments. Britain’s AstraZeneca will pay up to $6 billion to Japan’s Daiichi Sankyo under the drugmakers’ second multi-billion dollar oncology collaboration to develop and market a niche type of targeted cancer treatment.London-listed AstraZeneca said on Monday it would pay $1 billion upfront to Daiichi in staggered payments for an experimental drug called DS-1062, which belongs to a promising class of therapies called antibody drug conjugates (ADC).Further payments would depend on regulatory and sales milestones being achieved. The deal will not affect its 2020 earnings forecast, the British company said. An anti-TROP2 ADC called Trodelvy developed by Immunomedics won U.S. regulatory approval in April to treat an aggressive type of breast cancer, while Chinese firms Kelun Group and Bio-Thera Solutions are also working on TROP2-based biotech drugs.In a further boost to AstraZeneca’s oncology unit, two of its on-market therapies, one for lung cancer and another for blood cancer, won regulatory endorsements for expanded use in Europe.The company and Daiichi had signed a near $7 billion deal in 2019 for an ADC targeting the HER2 protein. The drug is now sold as Enhertu.The drugmakers have also been in talks over supply of the British company’s coronavirus vaccine in Japan.AstraZeneca shares were roughly unchanged at 8,644 pence by 0917 GMT.center_img Topics :last_img read more

Spain sets up Ebola ‘crisis committee’

first_img Tweet Share Share Warning messages about Ebola have appeared in public places in SpainSpanish PM Mariano Rajoy has set up a special committee to deal with the impact of Europe’s first case of Ebola.Mr Rajoy admitted that the situation was “complex and difficult”, but stressed that the government had a clear plan of what needed to be done.Spanish nurse Teresa Romero is said to be gravely ill, after catching the haemorrhagic fever while caring for patients brought from West Africa.The outbreak has killed more than 3,860 people, mainly in West Africa.More than 200 health workers are among the victims.Ebola is now entrenched in the capitals of the worst-affected states – Guinea, Liberia and Sierra Leone, the World Health Organization (WHO) says.‘Deep-clean’Speaking outside Madrid’s Carlos III hospital, where the 44-year-old Spanish nurse is being treated, Mr Rajoy said: “Our first priority is Teresa Romero – she is the only person that we know has the illness”.Prime Minister Rajoy (centre) said the government was clear about what needed to be doneEbola is taking a particularly heavy toll in LiberiaResults of the clinical trial span several countries in the region, and results will be sent to a team of expertsThe prime minister said the second key task was to find others who might have caught the virus and investigate how this happened.He was speaking as seven more people in Spain were being monitored in hospital for suspected Ebola.They include two hairdressers who came into contact with Ms Romero.The nurse’s apartment in Alcorcon, near Madrid, has been sealed.Notices outside the complex announce an ongoing deep-clean by emergency services, the BBC’s Lucy Williamson in Madrid says.On the driveway, there is a message of sympathy and hope, and a small scattering of candles can be seen, our correspondent adds.Ms Romero is believed to have become infected after touching her face with the glove of her protective suit while taking it off.Experimental serumMeanwhile, a senior health official told the BBC that leading global experts in the field had not anticipated the scale of the Ebola outbreak.Chris Dye from the WHO said the international response was helping, and the important thing now was to look forward.“We’ve asked for a response of about $1bn (£618m); so far we have around $300m (£185m) with more being pledged, so a bit less than half of what we need but it’s climbing quickly all the time,” he said.In April, the medical charity Medecins Sans Frontieres (MSF) warned of the potential spread of the virus, but at the time the WHO played down the claims, saying that Ebola was neither an epidemic, nor was it unprecedented.On Friday MSF reported a sharp increase of Ebola cases in the Guinean capital, Conakry, dashing hopes that the disease was being stabilised there.Meanwhile in Mali, an experimental serum is being tested on volunteer health workers.The trial spans several countries, and the results will be sent to experts to determine whether it can protect against Ebola.BBC News 141 Views   no discussionscenter_img HealthInternationalLifestylePrint Spain sets up Ebola ‘crisis committee’ by: – October 10, 2014 Share Sharing is caring!last_img read more

Fitness critical as Simmons eyes England tour

first_imgPORT OF SPAIN, Trinidad, (CMC) – West Indies head coach Phil Simmons has identified fitness as a key component during the ongoing lockdown due to the COVID-19 pandemic, and is hopeful the Test squad will be at an acceptable standard of readiness if the proposed tour of England goes ahead.According to Simmons, players had been undergoing fitness regimes – mostly at home – over the last month, and some had even stepped up outdoor preparation as their respective territories had eased curfew restrictions.“For the past four weeks or a little bit more than that, guys have been given different programmes and have been asked to even though they are locked away – because some territories had locked down very early – [to] find a room in their house or in their backyard to do work and keep themselves at a certain level of fitness,” the former West Indies player told i95FM Sport here.“As places have opened up, guys have been in some places been able to run on the beach and in other places go run outside but the training itself has been stepped up.“And even now it (Caribbean) has opened up a little more, you have a few guys who can go out and bowl on a pitch somewhere just to get their rhythm back so that’s how you have to progress.”He continued: “I don’t think that at this stage they’re enough facilities open where you can go and practice but they’re a few grounds where bowlers themselves can go and bowl.“There are no batsmen, only spot bowling, and we hope that this develops and develops and by the time if the tour comes off and we’re ready to leave, everybody would’ve done something at home.”While the tour is yet to be confirmed, Cricket West Indies chief executive said recently negotiations were at an advanced stage and he was “increasingly confident” the three-Test series would be played in July.If the matches come off, they will be played under strict social distancing and medical protocols, and at venues considered “bio-secure” facilities.Further, arriving players will be subjected to a two-week quarantine before moving to secure stadia where they will have no contact with the public.And even though matches will also be played without spectators present, the England-based Simmons believes there will be high pubic anticipation surrounding the series.“I think a lot of sport for a while is going to go ahead in front closed doors and I think the expectancy here is high because I think people want some kind of sport to go on,” he explained.“Sport is a part of life in England and even in the [football] Premiership, there’s a lot of talk about if it’s going to start back soon or not. But people are looking forward to sport coming back because the one thing that you’re missing here on the TV everyday is [live sport].“There’s a lot of old games being shown and people are enjoying that but they’re looking forward to live sport so there’s a lot of hope it happens but that depends on how things are put together.”The series will be the first international tour undertaken since world cricket was abruptly halted nearly three months ago due to the outbreak of the virus which has already caused nearly 5-½ million infections and 345 000 deaths globally.And despite the challenges facing the tour, Simmons said he was hopeful it could be played.“I’m hopeful it can happen but knowing the only way it can happen is if it’s properly safe for all the participants on both teams – players, coaches, umpires, commentators,” he stressed.“Everybody has to be safe and I think that’s the first thing they’re trying to make sure and that’s everyone is safe.”last_img read more

SU’s defense bends but doesn’t break in overtime win

first_img Published on September 19, 2015 at 7:00 pm Contact Matt: mcschnei@syr.edu | @matt_schneidman Facebook Twitter Google+ Scott Shafer admitted he was very nervous.Last night, the Syracuse head coach met with two of his own high school coaches and expressed worry about Central Michigan’s quarterback and wide receiving corps.And when Cooper Rush scrambled to his right with less than 10 seconds left and CMU down a touchdown, the floated ball that found the hands of Ben McCord — and stayed there as Julian Whigham fell on top of him in the end zone — brought Shafer’s nerves to fruition.“We did bend,” Shafer said, “… bent a little bit too much.”Despite cracking at the end of regulation, Syracuse didn’t break. Two fourth-quarter Central Michigan turnovers were erased and the Orange defense that held up a struggling offense for almost the entire second half had just 25 yards to work with in overtime.AdvertisementThis is placeholder textSyracuse’s last defensive possession resulted in three points for the Chippewas. But with CMU running back Devon Spalding firmly in the grasp of defensive end Ron Thompson on third down, SU’s (3-0, 1-0 Atlantic Coast) defense had done just enough to force a field goal and open the door for an unlikely offensive tandem to pull out a 30-27 win over the Chippewas (1-2) in the Carrier Dome on Saturday.“They were exploiting a lot of things on our defense, a lot of things that we need to work on,” linebacker Zaire Franklin said. “Really, it just comes down to having to make plays when we were called upon.”Syracuse didn’t score the entire second half as walk-on sophomore quarterback Zack Mahoney and sophomore Austin Wilson struggled to spark an Eric Dungey-less offense.The Orange had possession for only 8:53 in the second half, giving the defense more than 21 minutes to hold CMU to less than two touchdowns after Dungey helped construct a 14-point halftime lead.After Parris Bennett recovered a fumble in the fourth, Wilson threw an interception on the very next play. When Franklin intercepted a Rush pass, SU went three-and-out to force Riley Dixon into his sixth punt of the day.“It hurts,” offensive tackle Omari Palmer said. “As an offensive player our job is to ride the ball out, eat clock, eat clock. Get (the defense) rest, so they can stay fresh … they always do above and beyond … they really, really kept us in the game.”The Dome fell to a hush as McCord held onto the ball while his back hit the turf, and a 19-yard run by Spalding on the first play of overtime elicited the same reaction.Two plays later, with CMU facing a third-and-one on the 1-yard line, the band began blasting music at the opposite end of the field. Fans in the student section unleashed their jingling keys. And the third-down horn blared from the speakers.The snap to Rush and handoff to Spalding was met with quiet, but Thompson’s tackle for loss sparked a frenzy.It was a spark the offense couldn’t deliver until overtime, but one made possible by a defense stringent enough keep Syracuse afloat.“No matter what we do they can’t get across the goal line,” Franklin said. “Thankfully we made plays that stopped that.” Commentslast_img read more

Extra Innings: In baseball, anything can happen

first_imgSam Arslanian | Daily TrojanBaseball is the most exciting sport. I have played baseball for as long as I can remember, so it might be a bit biased for me to make this claim. But I have a justification for it. I am getting really tired of watching the same teams compete for championships. The New England Patriots win the Super Bowl seemingly every year, Alabama wins the College Football Playoffs and the NBA Championship is a toss up between the Warriors and the Cavs. It’s just boring now. Unlike its counterparts, the MLB hasn’t had a repeat winner since the 2000 season when the New York Yankees won their third World Series Ring in a row. In the College World Series, there hasn’t been a three-year championship streak since, oddly enough, the USC Trojans won five rings from 1970-1974. The average person can usually predict the winner of any basketball or football game by just picking the higher ranked team. On the other hand, in baseball, there is always the possibility that the absolute worst team in the league will upset the No. 1 seed. Think back to 2012. The Houston Astros had one of its worst seasons in franchise history. They finished with a laughable 55-107 record and ended 42 games behind the division-winning Cincinnati Reds and 33 games behind a wild card berth. To put it lightly, they were horrible, but they still beat the World Series Champion San Francisco Giants once that season. Not to mention the fact that just five years later the Astros went on to win the 2017 World Series.I have been following baseball for a long time, but before 2016 I had never heard of Coastal Carolina University. That year the Chanticleers seemingly came out of nowhere to knock off a dominant Texas Christian team to advance to the championship series, which they would win over Arizona. If that’s not exciting, then I don’t know what is. One of my gripes about other sports, particularly football, is that the seasons are too short. With 162 games, the MLB season is able to see past fluke wins and bad calls to determine the best 10 teams to play in the postseason.I understand that the frequency and amount of football games in a season cannot be increased because of health concerns. I merely appreciate the ability a baseball season has to predict the best teams to compete for the championship.Perhaps the most exciting part of this sport is that the game is not over until the last out is made. Every other major sport relies on a clock to signify the end of the game. In baseball, the pitcher is obligated to give the opposing team their chance to score runs. In the 2017 ALCS, the Detroit Tigers squared off against the Boston Red Sox. In the second game of the series, the Tigers led the Red Sox by a score of 5-2 entering the bottom of the eighth inning. As a Michigan native and Detroit Tigers fanatic, I felt very confident that the cats would pull out of that game with a win, but I knew the game wasn’t over. Unfortunately, I was right. In the bottom of the eighth, future Hall of Famer David Ortiz pounded a grand slam to put the Sox at equal score with the Tigers. That score held until the bottom of the ninth when Jarrod Saltalamacchia batted in Jonny Gomes to walk off the game.Thinking back to that game, I realized the implications of having to give the trailing team their chances. What if Tigers’ pitcher Max Scherzer was able to kneel the ball? Would the Tigers have advanced to the World Series and made a championship run? We will never know.With all of that being said, I look to USC Trojans baseball. The Men of Troy haven’t had a winning record since 2015 and finished the 2016 season with a measly .382 winning percentage. But I know in the sport of baseball there is always hope.Sam Arslanian is a freshman majoring in journalism. He is also the sports editor of the Daily Trojan. His column, “Extra Innings,” runs Mondays.last_img read more

Nwosu: Copa Coca-Cola Grooming Tomorrow’s Stars Today

first_imgencouraged to groom our stars of tomorrow, today,” says the former assistant coach at the 2002 World Cup and 2008 Beijing Olympics.The former footballer was a confidence booster to the young footballers at the coaching clinics for the Under-15 football teams participating in the ongoing COPA Coca-Cola tournament.The coaching clinics which took place ahead of the Southern regional finals in Port Harcourt was also co-chaired by ex-international footballer, Tajudeen Disu, who supported  Nwosu’s statement by adding that discipline, determination, and dedication are the ultimate prima needed to train these teens to become football stars and also help them achieve other future endeavours.Speaking on the coaching clinics, Nwosu said, “I am passionate about coaching clinics because it is one of the ways that Coca-Cola is encouraging our youths to leave the streets and be worthy ambassadors of this country and their families. Through Copa Coca-Cola, grassroots football can be encouraged to groom our stars of tomorrow, today.Nwosu, who remains the youngest Nigerian player to win the African Nations Cup, shared his teenage experience on combining education and football.“I am passionate about grassroots football because I started out exactly like some of these teens. I sneaked out of the house most afternoons just to play football because I was that passionate about it. My parents eventually decided to let me play football as long as I focused intently on my education and put in my best.“To prove to my parents that I could play football and still be studious, I worked twice as hard in class and on the football field and excelled. I want these teens to know that many doctors, lawyers, and military officials had managed to successfully play football and still excel in their education and jobs. If you want to play football, by all means, play but do not let your education suffer,” Nwosu said.Corroborating Nwosu’s statement, American-based Tajudeen Disu explains why grassroots football remains a priority on his agenda and why he is proud to contribute to the society through the Copa Coca-Cola coaching clinics.In Disu’s words “Back in the days, my team mates and I took our education as seriously as we took our love for football. Years later, we are glad we combined the two because it is the combination of the two that made us successful. These teens are rising football stars and could be recruited from within their secondary schools like I was. To build a future they can be proud of and retain their love for football, these teens need to take their education seriously too.”Reiterating his reason for participating in Copa Coca-Cola, Disu continued, “This is my second year of training teens in the Copa Coca-Cola coaching clinics and it has been an exciting experience for me. Big kudos goes to Coca-Cola for their continuous efforts in the development of grassroots football because this competition has the driving power to keep teens off the streets and give them a reason to remain in school.Speaking at the event, The Marketing Manager, Coca-Cola, Cletus Onyebuoha, expressed his appreciation for the continued support of the ex-internationals.“Coca-Cola strongly believes in the potential of Nigerian teens and we are well aware that football is a passion point for them. Through the trainings and motivation provided by our partnering seasoned ex-internationals, Copa Coca-Cola will continuously provide opportunities for skills acquisition and sports education.”Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegram Former Nigerian international, Henry Nwosu has praised Copa Coca-Cola in its drive at developing and growing future football stars for Nigeria.“Through Copa Coca-Cola, grassroots football can belast_img read more

FMCG Games End in StyleÂ

first_imgSpeaking during the closing ceremony, Jimmy Sogbesan – Chief Operating Officer, MediaVision Limited – organizers of the tournament, expressed delight at the enthusiasm showed by all participants and reiterated that the objective of the Games – creating a platform for all companies in the industry to relax, network, compete and have fun – was realized.At the end of the games; Friesland Campina emerged overall winners with eight gold, five silver and five bronze as well as becoming the Football Champions by edging out Unilever on goals difference.Unilever were runners up in the football event as well as on the overall medals table with two Gold, two Silver and two Bronze medals, BUA Group and UAC Foods won medals in various events.“We are the undisputed number one …. In the FMCG industry, we lead in industry best practices, fight to win with professionalism and inspire our people to always unleash their potentials,” FrieslandCampina Team Manager Kenneth Omeni boasted.Share this:FacebookRedditTwitterPrintPinterestEmailWhatsAppSkypeLinkedInTumblrPocketTelegram Leading beverage and foods company, FrieslandCampina Wamco has emerged champions of the fourth edition of Fast Moving Consumers Goods Games (FMCG).FrieslandCampina Wamco beating all comers to not only win the Football Gold but also emerge as Overall Champions at the games held at the Digital Bridge Institute Sports Complex, Oshodi, Lagos.The Games which brings together companies in the Fast Moving Consumer Goods industry to network, keep fit and have fun in a relaxed atmosphere witnessed participation in Athletics, Chess, Football, Scrabble and Table Tennis in the male and female categories.last_img read more

Altenar continues regulated market mission with Malta licence

first_img Global Gaming adds sportsbook extension to Ninja property August 25, 2020 Submit Share Share Related Articles Altenar: Supporting expansion plans in Denmark and Portugal August 20, 2020 Altenar has set about acquiring more customers from regulated gambling markets after collecting a B2B sports betting licence from the Malta Gaming Authority (MGA). This recognition allows Altenar to work with Malta-licensed operators to offer betting services including extensive in-play coverage and the popular cash out feature.The licensing process for this Type 2 B2B licence took just over five months which, according to Altenar CEO Stanislav Silin, is “relatively quick given that the regulatory regime in Malta changed in August 2018, and quite a number of providers had to go through the process of getting a new licence all at the same time”.The MGA licence covers a lot of common ground in terms of requirements typically present in country specific regulation, and is, therefore, a good base standard to cater for subsequent expansion into such jurisdictions.Silin added that securing the licence – which followed the firm’s approval to service the Romanian market in September 2018 – was a key stepping stone towards becoming “one of the best sportsbook providers on the market”.“This isn’t our first licence, as we already have one issued in Romania,” he explained. “It definitely won’t be the last either, but it is certainly the most significant so far, and one that should allow us to progress further along our path following our strategy of gaining recognition and acquiring customers in regulated markets. “Meeting the stringent compliance tests and regulatory requirements set by the MGA is definitely an important step as we seek to become one of the best sportsbook providers on the market – an ambitious vision that we are slowly making a reality.”It’s been a fast start to the year for Altenar, who secured its first regulated customer for the Romanian market in January through Red Sevens (www.redsevens.ro). Just two months later, the firm powered the launch of Fastbet.it, a new brand for established Italian sports betting and gaming operator Replatz – one of 70 licensees confirmed by the country’s gaming regulator Agenzia delle Dogane e dei Monopoli (ADM). TVBET passes GLI test for five live games in Malta and Italy August 25, 2020 StumbleUponlast_img read more

Tuka tested at the European Championship in Amsterdam two times by mistake?

first_imgAthletic Federation of BiH appealed to the International Association of Athletics Federation (IAAF) on double doping test of the best BH athlete Amel Tuka.Anti-doping administrator of the International Association of Athletics Federations (IAAF) Thomas Capdevielle responded to the protest note of the Athletic Federation of BiH which complained to the Department of Anti-Doping of the IAAF because of double testing of Tuka during the European Championships in Amsterdam, according to the statement of the Athletic Federation of BiH.During the championship, they took blood and urine samples from Tuka twice, and the second test was performed on the day of the finals. From the eight finalists of the race at 800 meters, Tuka was the only one tested, as stated from the Athletic Federation of BiH.In response of IAAF was stated that  they mistakenly took a sample of blood and urine from Tuka that day due to misinterpretation of instructions. According to the letter, the service provider (the World Anti-Doping Control) informed the IAAF about the mistake and apologized.Capdevielle apologized to our athlete and the Athletic Federation of BiH on behalf of the Department of Anti-doping control at the IAAF and thanked for their support in the fight against doping in sport.(Source: Radiosarajevo.ba)last_img read more

Peace River politicians react to Hill announcement

first_imgHill has been involved in politics for several decades, first running as a candidate for the Reform party in 1988. He has served the riding in the House of Commons since 1993 and was appointed as Leader of the Government in the House by Prime Minister Stephen Harper.The seat in the House will now be up for the taking and the question remains of who will be running in Hill’s place. The Member of Parliament for the Prince George – Peace River riding has announced he is not seeking re-election. Many public figures in the region discussed their feelings about Hill’s announcement.The MLA for Peace River South, Blair Lekstrom, says he thinks Hill has done a great job for the people in the Peace Region and wishes him well in his future. He added that whoever replaces Hill will have to work hard to accomplish as much as Hill has for the riding.- Advertisement -[asset|aid=3031|format=mp3player|formatter=asset_bonus|title=97c01098f7013646b8559d71d5b63631-Lekstrom – Reaction_1_Pub.mp3] The Mayor of Fort St. John, Bruce Lantz, says Hill has been a good friend of his for many years and that although he understands his decision, he will be sorry to see him end his career as a member of the federal government.[asset|aid=3032|format=mp3player|formatter=asset_bonus|title=97c01098f7013646b8559d71d5b63631-Lantz – Reaction_1_Pub.mp3] Advertisement Lantz added that he hopes he can have the same respectful relationship with the next MP as he has had with Hill.Karen Goodings is the chair of the Peace River Regional District and says she feels Hill has worked very hard for the region but respects the fact that he is going to pursue other interests.She says it will be difficult to find someone who can represent the geographically large area that Hill has strongly represented over the years.[asset|aid=3033|format=mp3player|formatter=asset_bonus|title=97c01098f7013646b8559d71d5b63631-Goodings – Reaction_1_Pub.mp3] Advertisementlast_img read more